Opportunities and challenges of mRNA technologies in development of dengue virus vaccine

Opportunities and challenges of mRNA technologies in development of dengue virus vaccine

Blog Article

Dengue virus (DENV) is a mosquito-borne virus with a significant human health concern.With 390 million infections annually and 96 million showing tennessee titans dog bandana clinical symptoms, severe dengue can lead to life-threatening conditions like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS).The only FDA-approved vaccine, Dengvaxia, has limitations due to antibody-dependent enhancement (ADE), necessitating careful administration.The recent pre-approval of TAK-003 by WHO in 2024 highlights ongoing efforts to improve vaccine options.

This review explores recent advancements in dengue vaccine development, emphasizing potential utility of mRNA-based vaccines.By examining current clinical trial data and innovations, we aim to identify promising strategies to address the limitations of existing vaccines and enhance 2014 dodge ram 1500 fender flares global dengue prevention efforts.